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Fig. 6. Myotube adhesion versus prestress. (A) Schematic of a sectioned myotube illustrates the balance between the prestress imposed by the actomyosin cytoskeleton (PA, PM), and the adhesive tension of the focal adhesions (TFA). (B,B') Schematic of the adhesive energetics, contractile stress, and adhesive tension during differentiation. After fusion, myotubes growing on rigid substrates progress to a tightly bound state with high adhesive tension. Cells growing on soft substrates, including other cells, exhibit a reduced adhesive tension and a shallower adhesion energy at this nascent myotube phase. This allows the latter to progress to a fully striated state of high prestress.





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