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Fig. 4. Ki67, Cdc6, Cdt1, Mcm2, and Geminin protein expression in human seminiferous tubules (original magnification x400). The schematic drawing (Top left) of a seminiferous tubule (cross section) shows the basal compartment (BC) containing stem cell spermatogonia directly in contact with the basement membrane (arrow 1). The differentiating luminal compartment (LC) contains germ cells in meiosis and postmeiotic phases. Maturing spermatogonia enter meiosis and become primary spermatocytes (arrow 2). Primary spermatocytes reside in a prolonged prophase of MI. Completion of MI and MII produces haploid early spermatids (arrow 3) with further differentiation giving rise to late spermatids (arrow 4). Ki67 expression is restricted to the BC. The majority of primary spermatocytes and early spermatids express Mcm2 including a subpopulation of spermatogonia. High levels of Geminin are detected in the LC. The majority of primary spermatocytes show strong immunostaining for Geminin. A small number of spermatogonia express Geminin (arrowhead). Expression of Cdc6 and Cdt1 is found in significant numbers of primary spermatocytes (thin arrows) and a subpopulation of spermatogonia (thick arrows).





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