spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 5. The proliferation-differentiation switch in colon and loss of DNA replication competence are coupled to downregulation of Ki67, Cdc6, Cdt1 and Geminin. In testis, the proliferation-differentiation switch and loss of DNA replication competence are also coupled to downregulation of Ki67. However, in contrast to somatic cells, early stages of germ cell differentiation and entry into meiosis are associated with high levels of Cdc6, Cdt1, Mcm2 and Geminin. Late stages of differentiation in somatic and germ cell self-renewing systems are linked to downregulation of Cdc6, Cdt1, Mcm2 and Geminin. Note that in contrast to Ki67, Cdc6, Cdt1 and Geminin, downregulation of Mcm2 is coupled to the final stages of the differentiation programme. BC, basal compartment; LC, luminal compartment; TDC, terminally different compartment; SG, spermatogonia; SC, primary spermatocytes; EST, early spermatids and late spermatids (LST)





Right arrow Return to article