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First published online November 24, 2004

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Lapping up nuclear assembly

The nuclear lamina is a highly organized scaffold beneath the nuclear envelope. It has a structural role and probably underpins interphase chromosome architecture by anchoring chromatin components. But what happens to the lamina when the envelope breaks down at mitosis, and how is order reestablished? Roland Foisner and co-workers have approached these questions by using live-cell imaging to track the behaviour of fluorescently tagged lamina components and chromatin at mitosis (see p. 6117). They find that a key lamina-associated protein, LAP-2, specifically associates with telomeres during anaphase. As telophase progresses, it becomes clustered at so-called `core' structures in chromatin on either side of forming nuclei. The LAP-2 clusters bind to BAF - an essential DNA-binding protein - and also attract lamin A/C and another lamina component, emerin. Lamin B, the lamin B receptor and LAP-2ß, by contrast, initially associate with more peripheral chromatin, before spreading to the core regions later on. The authors' findings are the first to implicate telomeres in assembly of the nuclear envelope/lamina. They also indicate that BAF-LAP-2 interactions might play an important part in the dynamic reorganization of chromatin after cell division.

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Related articles in JCS:

LAP2 and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly

Thomas Dechat, Andreas Gajewski, Barbara Korbei, Daniel Gerlich, Nathalie Daigle, Tokuko Haraguchi, Kazuhiro Furukawa, Jan Ellenberg, and Roland Foisner
JCS 2004 117: 6117-6128. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?