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Fig. 4. Inhibitors of G ${alpha}$ s- and G ${alpha}$ q-mediated signaling interfere with normal Ca²⁺ release at fertilization. (A) Ratiometric quantification of normal Ca²⁺ release at fertilization. (B) Anti-G ${alpha}$ s (100 µg/ml final concentration in egg) and Ca²⁺ release at fertilization. (C) G ${alpha}$ q peptide (50 µM final concentration in egg) and Ca²⁺ release at fertilization. Each data point represents an average of 3-8 recordings (error bars, 1±s.d.). (D) Ca²⁺ wave in a control egg (top left; pseudocolored); compare with the abnormal pattern in a G ${alpha}$ q peptide-injected egg (bottom right, observed in 42.5% of eggs). The images were independently adjusted to better reveal the features (wave versus spikes); colors reflect normalized fluorescence ratios of individual pixels (see side bars).

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