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Fig. 5. S17 within Src is phosphorylated by NGF in a PKA-dependent manner in PC12 cells. (A) Time course of Src phosphorylation by NGF at S17 and Y416. PC12 cells were stimulated with NGF or EGF for the indicated times, or left untreated (Un). After Src immunoprecipitation, precipitates were analyzed for phosphorylation of Src at S17 and Y416. Total Src levels are shown as a loading control (lower panel). (B) PKA-dependent Src phosphorylation by NGF. PC12 cells were stimulated with NGF for 15 minutes in the presence or absence of H89 and Src phosphorylation was analyzed at S17 and Y416 as described in A. Total Src levels are shown as a loading control (lower panel). (C) Inhibition of NGF induction of Src phosphorylation at S17 by Rp-cAMP. PC12 cells were stimulated with NGF for 15 minutes in the presence or absence of Rp-cAMP, and Src phosphorylation was analyzed at S17 (upper panel) as described in A. Total Src levels are shown as a loading control (lower panel).





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