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Fig. 7. Intranuclear membranes formed by lamin mutants containing a CxxM motif and N-terminal deletions. (A-C) Electron micrographs of ultrathin sections through microinjected (A,C) or transfected (B) Xenopus A6 cells expressing Drosophila lamin C-CxxM-N1 (A), Xenopus lamin B2-N1 (B) and Xenopus Lamin B2-N2 (C). Lamin mutants containing the complete helix 2 (A) or the C-terminal half of helix 2 (B) can induce the formation of multi-layered nuclear envelopes. (C) Mutant B2-N2 induced the formation of intranuclear spherical assemblies of multiple membrane cisternae that were in contact with the nuclear envelope. Note that the layers between adjacent cisternae (A,B) are less electron dense than in cells expressing wild-type lamins. cy, cytoplasm; ne, nuclear envelope; nu, nucleoplasm. Bars, 500 nm.

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