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Fig. 4. Tau-MT interaction is highly dynamic. (A-E) Series of fluorescence micrographs of Xenopus fibroblasts (A,C), Xenopus neurons (B,D), and human 356 fibroblasts (E) expressing GFP-tau. The first images were acquired immediately before photobleaching. Individual MTs are marked with arrows in A and B. Elapsed time after photobleaching is shown in seconds at the right corner of each image. The boxed regions mark the approximate location of the bleached zone. The size of the bleached regions is {approx}4 µm. For each time-lapse sequence, the background-subtracted fluorescence intensity of MTs (arbitrary units) was plotted against time in seconds. Fluorescence recovery after photobleaching along individual MTs (A,B,E) is rapid and uniform along MT length. Fluorescence recovery for neurite-like processes produced by fibroblasts (C) and for axons (D) is much slower.





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