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Fig. 6. Taxol induces rapid dissociation of tau from MTs. (A-F) Fluorescence micrographs of fibroblasts (A,C,D,F) and a neuron (B,E) expressing GFP-tau. Images were taken before exposure to drugs (top images), 3 minutes after application of 1 µM taxol (D,E), and 10 minutes after application of 1 µM vinblastine (F). MTs are clearly visible before drug application (arrows). After incubation with taxol, most of the individual MTs are not decorated with tau; only MT bundles (arrowheads) are seen. Incubation with vinblastine resulted in some MT depolymerization; however, tau is still associated with single MTs (arrows). Bar, 10 µm.





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