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Fig. 5. Effects of RyR1 inhibition on NFAT and MEF2-mediated transcription. PM muscle fibers transfected with either NFATLuc or MEF2Luc sensor constructs were co-cultured with spinal cord explants for innervation with and without 100 µM ryanodine in the culture medium. Data are expressed relative to sensor activities in noninnervated PM muscle fibers incubated in control medium. Innervation or ryanodine alone did not significantly increase NFAT or MEF2-mediated transcription, whereas both innervation and ryanodine significantly increased both NFAT and MEF2 transcriptional activity (P<0.05). SRE-mediated transcriptional activity did not significantly increase with ryanodine treatment or innervation, or both. Bars represent means±s.e.m.; n=6.





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