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Fig. 1. Alignment of the deduced amino acid sequence of the AmSFK1, AmSFK2 and AmSFK3 cDNAs with that of human Src (GenBank accession number P12931). Dashes indicate identity and dots represent gaps in the alignment. The unique N-terminal domains are followed by the SH3 domain (green), the SH2 domain (red) and the kinase domain (blue) (Xu et al., 1999). The conserved tyrosines of the activation loop (huSrc Tyr419) and the C-terminus (huSrc Tyr527) are indicated by asterisks. Key residues in the Src SH2 domain that are thought to contribute to binding specificity are indicated in bold font and predicted structural assignments ({alpha} helices and ß strands) are indicated (Kuriyan and Cowburn, 1997). The C-terminal sequence of huSrc that serves as the antigen for the sc-18 antibody (see Materials and Methods) is boxed.





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