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Fig. 5. Delay in securin degradation by removal of its D box. Mouse eggs expressing securin^dm were inseminated and egg activation monitored. The destruction of securin was significantly delayed by removal of its D box. (A) Representative securin^dm::GFP images captured from an inseminated egg every 2 hours at the times indicated (in hours). In this egg, polar body extrusion occurred at 2.8 hours and pronucleus formation at 5.6 hours. Scale bar: 20 µm. (B) The securin^dm::GFP profile in a fertilized egg. Ca²⁺ spiking, initiated at 1.5 hours, induced second polar body extrusion at 2.3 hours but during this time securin^dm was stable. At the time of polar body extrusion degradation of securin^dm began, and this continued until pronucleus formation at 7 hours.

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