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Fig. 1. Spatially heterogeneous Ca²⁺ transients during EC-coupling in atrial myocytes. (A) A representative myocyte displaying Ca²⁺ transients at a series of time points (in mseconds) after depolarisation of the cells. Transients were restricted to the junctional periphery. The solid white line denotes the position of the nucleus (N) and the dotted line indicates the cell periphery. The times noted on top of the images indicate the instances at which the images were taken relative to cell depolarisation. (B) A quantitative analysis of the propagation of electrically evoked Ca²⁺ signals in an atrial myocyte. The cell is depicted in i and the six regions from which the Ca²⁺ signal was sampled are indicated running transversely across the cell (denoted `A' to `F'). The average amplitude (ii) and rate of rise of the calcium signal (iii) in each region were calculated from six successive depolarisations, and are shown as mean±s.e.m. ^*Significantly different (P<0.05) from the response in region A. Please note that before each experimental recording, cells were paced until they had reached a steady-state condition.

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