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Fig. 8. Endothelin-1 promotes atrial myocyte contraction by increasing the response of non-junctional RyRs. (A) A cell image showing the locations of the subsarcolemmal site (red circle) and the central non-regenerative region (black circle) that were analysed. (B,C) The response of a typical atrial myocyte under control conditions and following a 5-minute incubation with 0.1 µM ET-1. The red and black traces illustrate the Ca2+ response in the subsarcolemmal and central region, respectively. The dashed black line on the cell image shows the portion of the cell that was sampled in generating the pseudo-linescan plots. Similar responses were observed in eight other cells (from three hearts).





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