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Fig. 7. A clonal cell line expressing N750 induces chromosomal instability. The two clonal cell lines, pLP-Myc and pLP-N750, were analysed as described in the other figures. (A) Bar chart of mitotic index after incubation in 0.2 µg/ml nocodazole for 18 hours. (B) Line graph plotting mitotic index during a 48-hour exposure to 0.2 µg/ml nocodazole. (C) Line graph plotting change in mitotic index over time following release from a nocodazole block. Myc control cells (squares) and N750 cells (triangles) were released into medium containing either nocodazole (solid symbols) or drug free medium (open symbols). Cells expressing N750 exit mitosis faster than controls. (D) Metaphase spread showing the presence of rearranged chromosomes (arrowheads and enlargements) in the N750 line.





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