JCS01580 Supplementary Material

Files in this Data Supplement:

• Movie 1 -

  Fig.S1: Top: Time-lapse movie, showing melanosome dynamics in control (Myo7a^4626SB/+) RPE cells. Melanosomes were mostly stationary, interrupted by very short bursts of rapid movement (>1 mm/sec). Images were captured every 500 milliseconds (frame rate=30 fps). Time-lapse movie, showing melanosome dynamics in mutant (Myo7a^4626SB/4626) RPE cells (bottom). Melanosomes are much more motile than in the control, with more than twice as many melanosomes showing rapid displacements (>1 mm/second) that travel, on average, five times longer. Images were captured every 500 milliseconds (frame rate=30 fps).