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Fig. 4. Light (A,B) and electron (C,D) micrographs of the RPE from ashen mice. (A,C) Control (Rab27a^+/ash), (B,D) mutant (Rab27a^ash/ash). The mice were on the C3H/HeSn background, which includes the rd1 mutation. Retinas were obtained from 14-day-old animals. No photoreceptor outer segments are evident owing to the initiation of photoreceptor degeneration, however, at this stage, the RPE remains unaffected by the degeneration. Arrows in A and B indicate the apical region of the RPE, which is completely devoid of melanosomes in the mutant. Arrows in C indicate melanosomes partially contained within the apical processes. Arrow in D indicates the apical processes, with melanosomes some distance away. A is the same magnification as B (bar, 10 µm) and C is the same as D (bar, 100 nm).

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