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Fig. 6. Electron micrograph of the RPE from a shaker1 control (Myo7a+/4626SB) mouse retina immunolabeled with myosin VIIa antibody (10 nm gold particles). The apical region is lower right and the basal region is upper left. In the apical region of the RPE cell, melanosomes are oriented along the axis of the apical processes. Myosin VIIa is present both on the melanosome membrane (circles) and unassociated with the melanosomes, elsewhere in the cytoplasm (arrows). Insert is a magnification of the square in the picture, showing two gold particles associated with the melanosome membrane. Bar, 300 nm.





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