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First published online December 31, 2003

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Modelling membranes for meiosis

During sporulation in yeast, a diploid mother cell divides meiotically to generate four haploid spores. Each of these must be surrounded by a forespore membrane (FSM), which the cell generates de novo within its cytoplasm. In a Commentary on p. 389, Chikashi Shimoda, discusses recent work showing that FSM formation is coordinated by spindle pole bodies (SPBs) – the yeast version of centrosomes. These recruit novel components such as Mpc54 to their outer plaques during the second meiotic division, which initiate FSM formation. GFP tagging of the FSM proteins Spo3 and Psy1 has allowed researchers to trace the FSM as it extends out from the SPBs to envelope each haploid nucleus. Spo3 is a novel potential membrane protein, whereas Psy1 is a homologue of the mammalian protein syntaxin 1A, a component of the SNARE complexes that drive vesicle docking/fusion. Indeed, homologues of several SNARE proteins are implicated in sporulation, including synaptobrevin and SNAP25, which indicates that vesicle fusion drives FSM assembly. Given this machinery, Shimoda suggests that FSM formation provides a general model for regulation of membrane trafficking by microtubule-organizing centres, which could be applicable to other examples of de novo membrane formation, such as Drosophila embryo cellularization.

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Related articles in JCS:

Forespore membrane assembly in yeast: coordinating SPBs and membrane trafficking

Chikashi Shimoda
JCS 2004 117: 389-396. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?