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Fig. 1. Organization of mature synapses in the CNS. (A) Hippocampal neurons maintained in culture for 12 days were labeled with antibodies against cytoskeleton-associated proteins MAP2 (green), a marker of dendrites, and tau (red), a marker of axons. Antibodies against synaptic vesicle protein synaptophysin (blue) were used to label presynaptic boutons. Axons form multiple synaptic contacts with the dendrites and cell body (soma) of the neuron (arrows). (B) Hippocampal neurons maintained in culture for 12 days were stained with antibodies against synaptophysin (green) to label axonal terminals, and NMDA (blue) and AMPA (red) receptors to label excitatory postsynaptic specializations. Arrows show examples of excitatory synapses where synaptophysin-labeled presynaptic boutons are apposed to accumulations of AMPA and/or NMDA receptors. Intracellular accumulations of NMDA and AMPA receptors are also seen (arrowhead). Bar, 10 µm (A and B). (C) Organization of excitatory and inhibitory synapses in the CNS. For more details, see the text.





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