spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 2. Synaptic precursor organelles and cargo proteins. Presynaptically (upper part), at least two different types of synaptic precursor organelles are described. Pleiomorphic tubulovesicular organelles transport VAMP, voltage-dependent Ca2+ channel (VDCC), synaptic vesicle protein 2 (SV2), synapsin and amphiphysin. Another type of vesicle is characterized by its dense core and round appearance. These vesicles contain the presynaptic cytomatrix proteins Piccolo, Bassoon, the SNARE proteins syntaxin and SNAP-25, Rab3a/c and Rab3-interacting molecule (RIM), Munc18, Munc13, N-cadherin and VDCC. Synaptophysin is transported by pleiomorphic structures that are covered with spectrin-containing cytoskeleton. Whether these organelles belong to the same type as VAMP-containing vesicles or constitute another type remains to be determined. Postsynaptically (lower part), organelles containing NMDA and AMPA receptors constitute two different types of transport carriers. PSD95 is depicted in a diffuse pool, but also in association with vesicular structures that are distinct from NMDA and AMPA receptor-containing vesicles. It remains to be elucidated whether vesicular transport organelles contain NCAM pre- and postsynaptically.





Right arrow Return to article