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First published online January 16, 2004

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How yeast cells control separation

During cell division, complex signalling pathways ensure that the two daughter cells separate only when each has received a single complete set of chromosomes. Carlos Vázquez de Aldana and co-workers describe how, at high temperatures, the protein Swm1p is needed for the final stages of cell separation in Saccharomyces cerevisiae (see p. 545). Swm1p is a core subunit in the anaphase-promoting complex (APC), the E3 ubiquitin ligase that initiates the metaphase-anaphase transition and promotes mitotic exit once chromosome segregation is complete. The authors report that, at 38°C, swm1 cells – mutants lacking SWM1 – form chains instead of separating into single cells after chromosome segregation. This behaviour results from reduced expression of chitinase and other proteins involved in separation, all of which require the transcription factor Ace2p for their expression. The authors show that at 38°C Ace2p fails to move from the cytoplasm to the nucleus (as happens at 28°C) at the end of mitosis, and they speculate that this failure to relocalise is linked to incorrect inactivation of cyclin-dependent kinases in swm1 cells.

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Related articles in JCS:

Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae

Sandra Ufano, M. Evangelina Pablo, Arturo Calzada, Francisco del Rey, and Carlos R. Vázquez de Aldana
JCS 2004 117: 545-557. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?