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Fig. 4. Similar but distinct expression patterns of tenascin-W and tenascin-C in mouse embryos. Immunohistochemistry of tenascin-W and tenascin-C (as indicated) at E14.5 (A,B,E,F,I,J), E15.5 (C,D,G,H,K,L) and E16.5 (M-P). At E16.5 (M-P), double labelling is shown with tenascin-W in green, tenascin-C in red and overlap in yellow. Tenascin-W is expressed in the circular muscular layer (cml) of the stomach at E14.5 (A) and in the muscularis mucosa (mm) and muscularis externa (me) at E15.5 (C). At E14.5, tenascin-C is expressed in both the cml and longitudinal muscular layer (lml) of the stomach (B). At E15.5, tenascin-C is found in the mm, but staining in the me (i.e. combined cml and lml) is faint. Tenascin-C is expressed in the developing liver (l) at both E14.5 (B) and E15.5 (D), but tenascin-W is not. Tenascin-W is expressed in the cml of the ileum at E14.5 (E) and in both the me and mm at E15.5 (G). It is not seen in the colon (c). Tenascin-C is not detected in the ileum at either E14.5 (F) or E15.5 (H) but, unlike tenascin-W, it is expressed in the developing musculature of the colon at E15.5 (H). At E14.5, tenascin-W is not present in the cartilaginous vertebral arches (va, I), but expression appears at E15.5 in the periosteum (po) around the ribs (K). Tenascin-C was expressed at both embryonic stages in the cartilaginous vertebral arches (J) and rib cartilage (ca, L). At E16.5, tenascin-W was expressed in mandible (m, M), palate (p, N) and molars (mo, O), mostly as a subset of tenascin-C expression (e.g. arrow, O). At the same stage, only tenascin-W was expressed in the matrix of the masseter (ma, P). sn, spinal nerve; oc, oral cavity; g, salivary gland. Scale bar, 200 µm.
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