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Fig. 3. DEP-1 expression reduces PDGF-induced tyrosine phosphorylation. Cells were quiesced for 4 hours then stimulated with 50 ng/ml PDGF. (A) Western blotting of whole cell lysates from PDGF-stimulated control 1A2 cells or DEP-1-expressing 2D3 cells with antiphosphotyrosine. (B) Western blotting of PDGF receptor immune precipitates with antiphosphotyrosine. (C) Association of c-src with PDGFR in DEP-1-expressing cells. DEP-1 expression reduces c-src association with PDGFR. Uninduced and induced NIH3T3 cells were stimulated with PDGF as described in Materials and Methods. PDGF receptor was immune precipitated and immunoblotted for c-src (upper panel) or PDGF (lower panel).





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