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Fig. 2. MBC is a more potent microtubule inhibitor than TBZ. Anti-tubulin immunofluorescence images of wild-type cells (A-G) treated with (A) DMSO, (B) 5 µg/ml MBC, (C) 10 µg/ml MBC, (D) 25 µg/ml MBC, (E) 50 µg/ml MBC, (F) 50 µg/ml TBZ or (G) 100 µg/ml TBZ; and benzimidazole-resistant nda3-TB101 beta-tubulin mutant cells (H-J) treated with (H) DMSO, (I) 50 µg/ml MBC or (J) 100 µg/ml TBZ. Similar microtubule distributions were seen at both 10 and 90 minutes of drug treatment (not shown).





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