QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

	Help viewing high resolution images
	Return to article

(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.

Fig. 8. Model of normal and dystrophic costameric patterns. Sarcolemmal basement membrane (bm), plasma membrane (pm), cortical cytoskeleton (cc) and underlying sarcomeres (sm) are shown. Normal (wild-type, wt) basement membrane, although continuous, is condensed into circumferential Z (major) and M (minor) bands and longitudinal (L) striations that correspond to the same pattern elements seen with ß1-integrin and dystroglycan receptors and cytoskeletal vinculin and dystrophin. The basement membrane, receptor and cytoskeletal dy^2J lattice-like patterns become generally effaced while the receptor (dystroglycan, this study) and cytoskeletal (spectrin) (Williams and Bloch, 1999) M and L elements of mdx muscle are lost, with less-pronounced changes in the laminin pattern.

Return to article