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Fig. 3. Electron microscopic visualization of the modulation of chromatin structure induced by synthesis and degradation of poly(ADP-ribose). The condensed chromatin superstructure (A) was relaxed by a 60 minute incubation with purified poly(ADP-ribose) polymerase in the presence of 200 µM NAD (B). Poly(ADP-ribosyl)ated chromatin re-condensed by a 60 minute incubation with purified poly(ADP-ribose) glycohydrolase (C). The arrows in (B) point to automodified PARP-1 molecules. Chromatin was fixed and spread in 40 mM NaCl. Bar, 0.1 µm. Reproduced with permission from de Murcia et al. (de Murcia et al., 1986).





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