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Fig. 5. Replacement of tyrosine 125 in ${alpha}$ -synuclein by aspartate or phenylalanine does not affect ${alpha}$ -synuclein transport rate in rat cortical neurons. Rat cortical cultures transfected with plasmids expressing EGFP-tagged human wild-type or the Y125D or Y125F mutants of ${alpha}$ -synuclein, and their distributions were compared by direct fluorescence 4.5 hours after transfection. Scale bars, 50 µm. Human wild-type (black), Y125D (white) and Y125F (grey) ${alpha}$ -synuclein plasmids were transfected into 5 DIV rat cortical cultures. Bars indicate the mean rates of transport ± s.e.m. (µm hour^–1) for each construct between 3 hours and 4.5 hours after glycerol shock (n=52-121 neurons).

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