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Fig. 2. Effect of caffeine and A23187 on Ca2+ efflux from non-permeabilised wtRyR- and V2322DRyR3-expressing HEK293 cells. (A) 45Ca2+ efflux was measured in wtRyR3 (squares) and V2322DRyR3-expressing cells (circles) in Ca2+-free medium. After 8 minutes, cells were challenged for 2 minutes with 10 mM caffeine. (B) The total-releasable Ca2+ was measured by challenging the cells with 10 µM A23187 in wtRyR3- (squares) and V2322DRyR3-expressing cells (circles) in the same medium. The results are plotted as fractional loss as a function of time. Representative traces from five independent experiments are shown. Data points are given as mean±s.d.





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