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Fig. 4. Rac1–/– BMMs have a reduced ruffling response to CSF-1. CSF-1-starved (A,B) and CSF-1-stimulated BMMs (C,D) were fixed and stained for F-actin with TRITC-phalloidin. Arrows indicate membrane ruffles. (Inset) An example of a Rac1–/– BMM that has a full ruffling response to CSF-1. Scale bar: 10 µm. (E,F) Quantification of changes in adhesive area (E) and cell elongation ratio (ratio of the longest to the shortest cell axes; F) in growing, starved and CSF-1 stimulated WtCre and Rac1–/– BMMs. The results shown are mean±s.e.m. of >=100 cells from each population over two separate experiments. Statistical significance compared to WtCre growing values was calculated using Student's t-test, *P<0.05; ***P<0.001.





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