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First published online March 2, 2004

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Meiotic choreography

During meiosis, diploid cells replicate their DNA and then undergo two rounds of division – meiosis I and II – without further DNA replication to yield haploid germ cells. During meiotic prophase I, pairing and recombination of homologous chromosomes ensures their correct segregation after the first round of division. On p. 1221, José Suja and co-workers propose that SCP3 – a protein present in the lateral elements of the synaptonemal complexes that hold the chromsomes together – and the cohesin Rad21 are involved in the monopolar orientation of sister kinetochores (the proteinaceous structures that link centromeres to spindle microtubules) during mouse meiosis I. The authors use a squashing technique to prepare mouse spermatocytes for a detailed immunocytological analysis of where and when SCP3, Rad21 and some additional chromosomal proteins interact with chromosomes during meiosis. They show that SCP3 and Rad21 accumulate at centromeres in late prophase I but are displaced during telophase I when the sister kinetochores separate. Importantly, SCP3 and Rad21 are not present at metaphase II centromeres and so cannot be involved in sister-chromatid centromere cohesion during meiosis II as previously thought.

Related articles in JCS:

Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I

María Teresa Parra, Alberto Viera, Rocío Gómez, Jesús Page, Ricardo Benavente, Juan Luis Santos, Julio S. Rufas, and José A. Suja
JCS 2004 117: 1221-1234. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content