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Fig. 1. v-Src, or activated Src527F, induces tyrosine phosphorylation of cell-cell adherens junction components (the cadherin/catenin system), or acts by phosphorylating protein regulators of adherens junctions, such as Hakai, to cause disruption, or weakening, of cell-cell adhesions. Internalised cadherin molecules and released binding proteins are indicated. In a somewhat analogous manner, oncogenic Src weakens the links between cell-matrix adhesions and the actin cytoskeleton in the cell interior, in some situations by causing phosphorylation of the integrin cytoplasmic tails, but also by phosphorylating R-Ras and causing a change in integrin activation status.
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