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Fig. 3. Epithelial cells that are held together by intercellular contacts (top-left), and shown for cells from the KM12C colon cancer cell series (visualized by immunofluorescence) (top right), become dispersed as a consequence of expression of Src527F (bottom-left), shown for KM12C cells (bottom-right). As described in the text, cadherin-dependent cell-cell contacts are lost and assembly of integrin-associated adhesions are enhanced as a result of oncogenic Src, resulting in the `adhesion switch' phenotype associated with acquisition of a more mesenchymal-like morphology. Cells in the top-right and bottom-right panels are stained with anti-E-cadherin and anti-vinculin, respectively. Images are courtesy of Egle Avizienyte.
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