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Fig. 7. A proposed model for the selective use of S/MAR for transcription/replication regulation. The left panel shows a gene located on the loop with a S/MAR in close proximity. When functional demands require the specific association of this gene with the transcriptional machinery located on the nuclear matrix, the S/MAR moves the gene to the nuclear matrix, thereby initiating gene expression (center panel). Following initiation, the gene is pulled in through the transcriptional machinery, thus completing the process (right panel). There are two types of S/MARs. Functional S/MARs serve as mediators to bring genes onto the nuclear matrix. Structural S/MARs serve as anchors, which are less dynamic compared with functional S/MARs.





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