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Fig. 4. Multiple signalling pathways controlled by Cdc42. Cell polarization requires the spatial and temporal regulation of several cell components. Orientation of the actin and microtubule cytoskeletons, regulation of cell contacts and organization of membrane traffic occur in concert. Multiple signalling pathways downstream of Cdc42 regulate these different cellular components (black box). These signals are transduced by different Cdc42 direct (solid line) or indirect (dotted line) effectors (blue) and involve several intermediates (blue). Cell polarization results from the localized activation of Cdc42, which leads to a localized regulation of cellular components and therefore to their asymmetric organization. The different cellular components cooperate and generate the general characteristics of cell polarization.





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