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Fig. 2. Phylogenetic tree of the Rho-family GTPases and representatives of other Ras-superfamily GTPases. A phylogenetic analysis of the amino acid sequences of the Rho domains of the 22 Rho-family members made with ClustalW, together with functional data (see text) shows that the family can be roughly divided into six major branches: RhoA-related, Rac-related, Cdc42-related, Rnd proteins, RhoBTB proteins and Miro proteins.





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