|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
| ||||||||||||||||||||
Files in this Data Supplement:
Movie 1: Self-organization in the narrow elongated fragment as predicted by the 1D model. Initially, a homogeneous granule density is shown at the top and the polymer densities of MTs, calculated analytically, are shown in the middle and bottom. When dynein is stimulated, the granules aggregate to the center of the fragment, while the MT polymer density evolves into a shape demonstrating that most MTs have their minus and plus ends stabilized at the center and edges of the fragment, respectively.
Movie 2: Same as in movie 1, but now the polymer densities of MTs have three maxima in the fragment. This simulation shows that, initially, three local pigment aggregates emerge, which then merge into two transient aggregates and, finally, into one aggregate at the center of the fragment.
Movie 3: In the nascent fragment, initially the granules are uniformly distributed but the MTs are all oriented in the same way, with their minus ends at the left and their plus ends at the right. Initially, the granules aggregate near the left edge of the fragment. The aggregate shifts slightly toward the center but stops far from it. The MTs organize into an aster with their minus ends embedded in the fragment.
Movie 4: Self-organization in the square fragment as predicted by the 2D model. Initially, the granule density is homogeneous (illustrated by shading, with darker shading corresponding to higher density) and MTs (with light minus ends and darker plus ends) are distributed randomly. When dynein is stimulated, the granules merge into a few local aggregates subsequently coalescing into a single aggregate. Then, MTs with the minus ends outside of the aggregate treadmill toward the boundary and disappear as a MT aster emerges from the aggregate.
Movie 5: Aggregation of the pigment granules as observed experimentally in two fragments of different sizes and shapes.
Movie 6: Aggregation of the pigment granules as observed experimentally in the bi-lobed fragment.
Movie 7: Computer simulated aggregation of pigment granules and MT aster formation in the bi-lobed fragment.
| ||||||||||||||||||||
