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Fig. 8. Repression of Bub1, BubR1, Cenp-E, Aurora B and Survivin result in distinct alignment defects. (A) Immunofluorescence images showing examples of alignment defects after repression of Bub1, Cenp-E, BubR1, Aurora B and Survivin in DLD-1 cells that were fixed and stained to detect DNA (blue) and Aurora A (red). (B) Percentages of normal and abnormal metaphases with incomplete congression at the metaphase plate (as shown in A) after repression of Bub1 or Cenp-E. (C) Proportion of mitotic cells exhibiting prophase, prometaphase, metaphase and anaphase chromosome alignments after a 1-3 hour exposure to MG132. Values represent the mean and s.e.m. derived from three independent experiments in which at least 100 mitotic cells were counted. (D) Prometaphase/metaphase ratios from the 1 hour time point (C).





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