|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
|
Fig. 7. Model for asymmetric furrow induction through microtubule-mediated distribution of actin filaments in cut cells. Following cutting in early anaphase (a), chromosomes (blue) continue to move poleward (b,c), whereas actin filaments (red) and mitochondria (gray) accumulate toward exposed plus-ends of spindle microtubules (green). Spindle bipolarity begins to re-establish when short antiparallel microtubules organize a new half-spindle and overlap with cut plus-ends of the original half-spindle to form a new `midzone' (c). While mitochondria become aligned with spindle microtubules, actin filaments continue to follow microtubule plus-ends to the cell cortex where they bundle into a contractile ring and initiate an asymmetric furrow (d). The furrow ingresses as the new half-spindle elongates, shifting along with the midzone toward the middle of the central spindle (d,e).
|
