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First published online March 12, 2004

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STATs for JAKs

Signalling through receptors for cytokines and numerous growth factors activates members of the Janus kinase (also comically known as `just another kinase' or more simply JAK) family. These in turn switch on signal transducers and activators of transcription (STATs), which regulate transcription of various target genes. There are at least four JAKs and seven STATs in mammals - not to mention an array of endogenous inhibitors termed suppressors of cytokine signalling (SOCS). In Cell Science at a Glance (see p. 1281 + poster), Douglas Harrison and co-workers survey the JAK/STAT signalling pathway, detailing the various points at which crosstalk with other signalling mechanisms occurs, as well as the consequences of mutations in particular JAK and STAT genes.

Related articles in JCS:

The JAK/STAT signaling pathway

Jason S. Rawlings, Kristin M. Rosler, and Douglas A. Harrison
JCS 2004 117: 1281-1283. [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content