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Fig. 4. Snail-induced downregulation of occludin expression, but not claudin-1 expression, is ascribed to suppression of promoter activity. (A) Downregulation by Snail of junction protein expression in A431 cells. (B) The promoter region of human E-cadherin, occludin and claudin-1. E-boxes are indicated by open boxes. The putative transcription start point is denoted by +1. For occludin, two putative transcription start points are proposed (Mankertz et al., 2000). (C) Repression of the promoter activities of human E-cadherin and occludin, but not that of claudin-1, by Snail in A431 cells. Reporter constructs carrying the human E-cadherin, occludin or claudin-1 promoters were co-transfected with a pCAGGS-Snail vector or an empty pCAGGS vector. Whereas the promoter activities of E-cadherin and occludin were repressed by Snail, that of claudin-1 was not repressed. The results represent the mean±s.d. of two independent experiments.
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