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Fig. 4. Incorporation of EGFR into internal endosomal vesicles is inhibited by hVPS4^EQ. HeLa cells transfected with GFP-hVPS4^wt or GFP-hVPS4^EQ and incubated for 20 minutes with EGF were double labeled for GFP (15 nm gold) and EGFR (10 nm gold). (A) EGFR is found on internal vesicles of LEs in cells expressing hVPS4^wt. (B) In cells expressing hVPS4^EQ, EGFR (arrowheads) is retained at the limiting membrane of endosomal vacuoles (EV). L, lysosome; M, mitochondrion. Scale bars, 200 nm.

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