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Fig. 6. The hypercontraction phenotype of hdp3/+ heterozygotes. Polarized light micrographs of (A) wild-type IFM (the star indicates a single DLM and the diamond indicates the TDT) and (B) hypercontracted (arrowheads) IFM from hdp3/+ flies; note the hypercontracted TDT (arrow). Electron micrograph of transverse section (TS) of (C) normal, wild-type and (D) hdp3/+ heterozygote myofibrils showing the precise myofibrillar lattice of wildtype and the irregular and loose packing of the mutant myofibril, but with normal thick-thin filament lattice at its centre. Electron micrograph of LS of (E) wild-type myofibril showing the regular sarcomeres with their Z discs and M lines, and (F) of hdp3/+ myofibrils in which Z-discs (arrowheads) and M-lines (arrow) appear streamed. Bars, 0.12 mm (A,B); 0.63 µm (C-F).





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