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First published online December 22, 2004

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Epithelial migration: beneath the sheets

The movement of continuous sheets of epithelial cells occurs during embryonic development and tissue repair. It is generally assumed that active movement of the cells at the leading edge of a migrating cell sheet pulls the rest of the sheet along in a somewhat passive manner. Rizwan Farooqui and Gabriel Fenteany overturn this dogma by showing that, by extending lamellipodia beneath the cell sheet, multiple rows of cells behind an epithelial wound edge actively crawl along the substratum (see p. 51). The authors use confocal and two-photon microscopy combined with GFP-actin labelling and transmission electron microscopy to examine the cells behind the margin – submarginal cells – of a wounded epithelial cell monolayer. They report that these cells maintain their apical cell-cell contacts but extend basal lamellipodia that are hidden from conventional microscopy. Further work is now needed to reveal how the migratory behaviour of individual cells is coordinated to achieve collective cell migration.

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Related articles in JCS:

Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement

Rizwan Farooqui and Gabriel Fenteany
JCS 2005 118: 51-63. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?