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First published online December 22, 2004

Journal of Cell Science 118, 103e (2005)
© The Company of Biologists Limited
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In this issue

Epithelial migration: beneath the sheets


The movement of continuous sheets of epithelial cells occurs during embryonic development and tissue repair. It is generally assumed that active movement of the cells at the leading edge of a migrating cell sheet pulls the rest of the sheet along in a somewhat passive manner. Rizwan Farooqui and Gabriel Fenteany overturn this dogma by showing that, by extending lamellipodia beneath the cell sheet, multiple rows of cells behind an epithelial wound edge actively crawl along the substratum (see p. 51). The authors use confocal and two-photon microscopy combined with GFP-actin labelling and transmission electron microscopy to examine the cells behind the margin – submarginal cells – of a wounded epithelial cell monolayer. They report that these cells maintain their apical cell-cell contacts but extend basal lamellipodia that are hidden from conventional microscopy. Further work is now needed to reveal how the migratory behaviour of individual cells is coordinated to achieve collective cell migration.


Related articles in JCS:

Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement
Rizwan Farooqui and Gabriel Fenteany
JCS 2005 118: 51-63. [Abstract] [Full Text]  




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