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Fig. 8. The absence or inhibition of PARP-1 and PARP-2 has no repercussion on nucleolar transcription. Northern blot analysis of total RNAs obtained from the wild type (WT), PARP-1–/– (P1–/–), PARP-2–/– (P2–/–) or wild-type MEFs cultivated for 2 hours in the presence of 5 mM 3-AB (WT+3AB). Cells were either treated or not with the indicated agents. A typical experiment is illustrated. The upper panel shows the autoradiogram after hybridization of a 47S pre-rRNA specific probe; lower panel, staining of the membrane with methylene blue, showing the 28S and 18S rRNA as a loading control.





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