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Fig. 5. Transfection of active Akt-1 restores cell survival and inhibits p38 MAP kinase phosphorylation. (A) Statistical analysis of caspase-3 activity shows that transfection with myr-Akt-1 significantly blocks increases in caspase-3 activity in cells cultured in high glucose (HG) or peroxynitrite (PN) compared to cells transfected with ß-galactosidase (ß-gal). (*P<0.05 compared to ß-gal.) (B) Transfection with myr-Akt-1 decreases p38 MAP kinase phosphorylation in cells cultured in high glucose (HG) or peroxynitrite (PN) compared to cells transfected with ß-galactosidase. A representative image of immunoblot analysis of phospho p38 MAP kinase and ß-actin is shown at the top. Similar results were obtained in another two experiments. (*P<0.05 compared to NG, {dagger}P<0.05 compared to HG and PN.)





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