QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online May 12, 2005

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Getting a GRIP on Golgi positioning

In interphase vertebrate cells, the stacked cisternae of the Golgi complex are tethered next to the microtubule-organizing centre (MTOC). To achieve this central cellular position, a dynein-dynactin motor complex drives the migration of pre-Golgi membranes along microtubules towards the MTOC. Michael Marks and co-workers now report that the Golgi protein tGolgin-1 (also known as p230 or golgin-245) also functions in Golgi positioning (see p. 2279). tGolgin-1, a peripheral membrane protein, is associated with the trans-Golgi network (TGN) through its GRIP domain. The authors show that, in HeLa cells depleted of tGolgin-1 by RNAi, the Golgi and TGN are fragmented into `ministacks' (similar to those seen in cells where microtubules or dynein-dynactin motors are disrupted) and displaced to the periphery. They also show that tGolgin-1 is required for the retrograde transport of Shiga toxin to the Golgi. Putting these and other results together, the authors speculate that tGolgin-1 functions indirectly in Golgi positioning by regulating the retrograde movement of cargo required for the recruitment of microtubule motors to newly formed Golgi elements.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre

Atsuko Yoshino, Subba Rao Gangi Setty, Clare Poynton, Eileen L. Whiteman, Agnès Saint-Pol, Christopher G. Burd, Ludger Johannes, Erika L. Holzbaur, Michael Koval, J. Michael McCaffery, and Michael S. Marks
JCS 2005 118: 2279-2293. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?