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First published online May 12, 2005

Journal of Cell Science 118, 1001e (2005)
© The Company of Biologists Limited
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In this issue

Getting a GRIP on Golgi positioning


In interphase vertebrate cells, the stacked cisternae of the Golgi complex are tethered next to the microtubule-organizing centre (MTOC). To achieve this central cellular position, a dynein-dynactin motor complex drives the migration of pre-Golgi membranes along microtubules towards the MTOC. Michael Marks and co-workers now report that the Golgi protein tGolgin-1 (also known as p230 or golgin-245) also functions in Golgi positioning (see p. 2279). tGolgin-1, a peripheral membrane protein, is associated with the trans-Golgi network (TGN) through its GRIP domain. The authors show that, in HeLa cells depleted of tGolgin-1 by RNAi, the Golgi and TGN are fragmented into `ministacks' (similar to those seen in cells where microtubules or dynein-dynactin motors are disrupted) and displaced to the periphery. They also show that tGolgin-1 is required for the retrograde transport of Shiga toxin to the Golgi. Putting these and other results together, the authors speculate that tGolgin-1 functions indirectly in Golgi positioning by regulating the retrograde movement of cargo required for the recruitment of microtubule motors to newly formed Golgi elements.


Related articles in JCS:

tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre
Atsuko Yoshino, Subba Rao Gangi Setty, Clare Poynton, Eileen L. Whiteman, Agnès Saint-Pol, Christopher G. Burd, Ludger Johannes, Erika L. Holzbaur, Michael Koval, J. Michael McCaffery, and Michael S. Marks
JCS 2005 118: 2279-2293. [Abstract] [Full Text]  




This Article
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