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First published online May 12, 2005

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Joining sisters at the hip

Sister chromatid cohesion is essential for accurate genome segregation in mitosis and meiosis. The conserved cohesin complex is central to chromatid cohesion but other factors modulate the dynamic behaviour of cohesin during the cell cycle. One such factor is Pds5, a protein conserved from yeast to humans. On p. 2133, Tatsuya Hirano and colleagues describe the biochemical and functional characterization of the Pds5-related proteins Pds5A and Pds5B in vertebrate cells. They show that the Pds5 proteins physically interact with cohesin in HeLa cells and associate with chromatin in a cohesin-dependent manner. Depletion of either protein by RNA interference causes defects in sister chromatid cohesion, which are similar to but milder than those caused by depletion of cohesin components. In Xenopus egg extracts, depletion of both proteins has no apparent effect on arm cohesion but seems to loosen centromeric cohesion, even though high levels of cohesin are present on these chromosomes. These results lead the authors to propose that Pds5 proteins participate in both the stabilization and destabilization of cohesin-mediated cohesion.

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Related articles in JCS:

Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts

Ana Losada, Tomoki Yokochi, and Tatsuya Hirano
JCS 2005 118: 2133-2141. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?