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Fig. 1. Schematic representation of IQGAP1 mutants and interacting molecules. The numbers indicate the position of amino acid residues. Abbreviations: CHD, calponin homology domain; WW, domain with two conserved Trp (W) residues; IQGAP repeat, IQGAP-specific repeat motif; IQ motif, calmodulin-binding motif; GRD, RasGAP-related domain; RasGAP C, RasGAP C-terminus; ERK2, extracellular signal-regulated kinase 2; ELC, myosin essential light chain.





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