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Fig. 3. Schematic representation of the movement of microtubules along actin filaments. The coordinated reorganization of the cytoskeleton is essential for cell polarization and migration. Actin filaments are one candidate for guidance tracks for microtubules. Actin-binding proteins such as myosin VI interact with CLIP-190, the Drosophila homolog of CLIP-170, to slide microtubules along actin filaments. In higher eukaryotes, scaffold proteins such as ACF7 link actin filaments and microtubules. These actin-binding proteins and +Tips seem to stabilize mictotubule-actin interactions. They also stabilize cell migration or cell adhesion.





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